Health and Human Services Secretary Kathleen Sebelius came into office in the midst of the H1N1 public health crisis and faced a series of crises throughout the first Obama administration. Her focus was, at first, to marshal the resources she had at her disposal to address the crisis. But after the first wave of H1N1 passed, Sebelius was less focused on responding to the current threat and more focused on building new and enduring structures of collaboration within the government and across sectors to address future public health threats.